Therapeutic Indications

Cholic acid is indicated for:

3β-Hydroxy-Δ<sup>5</sup>-C<sub>27</sub>-steroid oxidoreductase deficiency

Irrespective of gender only Adults (18 - 65 years old)

Cholic acid is indicated for the treatment of inborn errors in primary bile acid synthesis due to 3β-Hydroxy-Δ5-C27-steroid oxidoreductase deficiency in infants, children and adolescents aged 1 month to 18 years and adults.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-15 mg/kg once a day

Δ<sup>4</sup>-3-Oxosteroid-5β-reductase deficiency

Irrespective of gender only Adults (18 - 65 years old)

Cholic acid is indicated for the treatment of inborn errors in primary bile acid synthesis due to Δ4-3-Oxosteroid-5β-reductase deficiency in infants, children and adolescents aged 1 month to 18 years and adults.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-15 mg/kg once a day

Contraindications

Active ingredient Cholic acid is contraindicated in the following cases:

Phenobarbital

No gender/age discrimination

Phenobarbital antagonises the effect of cholic acid. Use of phenobarbital in patients with 3β-Hydroxy-Δ5-C27-steroid oxidoreductase deficiency or Δ4-3-Oxosteroid-5β-reductase deficiency treated with cholic acid is contraindicated. Alternative treatments should be used.