Therapeutic Indications

Chlordiazepoxide is indicated for:

Acute alcohol withdrawal

Irrespective of gender only Elderly (65 years old or older)

Symptomatic relief of acute alcohol withdrawal.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 25-50 mg in 2-4 divided doses daily

Anxiety

Irrespective of gender only Elderly (65 years old or older)

Symptomatic relief of anxiety that is severe, disabling or subjecting the individual to unacceptable distress occurring alone or in association with insomnia or short-term psychosomatic, organic or psychotic illness.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-50 mg in 2-4 divided doses daily

Insomnia associated with anxiety

Irrespective of gender only Elderly (65 years old or older)

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-15 mg once daily

Muscle spasm

Irrespective of gender only Elderly (65 years old or older)

Muscle spasm of varied aetiology.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-15 mg in 1-3 divided doses daily

Acute alcohol withdrawal

Irrespective of gender only Adults (18 - 65 years old)

Symptomatic relief of acute alcohol withdrawal.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 25-100 mg in 2-4 divided doses daily

Anxiety

Irrespective of gender only Adults (18 - 65 years old)

Symptomatic relief of anxiety that is severe, disabling or subjecting the individual to unacceptable distress occurring alone or in association with insomnia or short-term psychosomatic, organic or psychotic illness.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-100 mg in 2-4 divided doses daily

Insomnia associated with anxiety

Irrespective of gender only Adults (18 - 65 years old)

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 10-30 mg once daily

Muscle spasm

Irrespective of gender only Adults (18 - 65 years old)

Muscle spasm of varied aetiology.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-30 mg in 2-4 divided doses daily

Contraindications

Active ingredient Chlordiazepoxide is contraindicated in the following cases:

Severe hepatic insufficiency

No gender/age discrimination

Lactation

No gender/age discrimination

Use during lactation should be avoided as chlordiazepoxide is found in breast milk.

Pregnancy

No gender/age discrimination

Chlordiazepoxide crosses the placenta.

There is a limited amount of data from the use of chlordiazepoxide in pregnant women.

Studies in animals have shown reproductive toxicity.

There is no evidence as to drug safety in human pregnancy. Do not use during pregnancy, especially during the first and last trimesters, unless there are compelling reasons (e.g. no alternative or benefit outweighs risk).

An increased risk of congenital malformations in humans has been associated with its use, particularly in the first and second trimesters. If the product is prescribed to a woman of childbearing potential, she should be warned to contact her physician regarding stopping if she intends to become or suspects she may be pregnant.

The administration of high doses or prolonged administration of low doses of benzodiazepines during the late phase of pregnancy or during labour has been reported to produces hypothermia, irregularities in fetal heart rate, hypotonia, poor-sucking and moderate respiratory depression, in the neonate. Infants born to mothers who took benzodiazepines chronically during the later stages of pregnancy may have developed physical dependence and may be at some risk for developing withdrawal symptoms in the postnatal period.

Cerebral ataxia

No gender/age discrimination

Phobic disorder

No gender/age discrimination

Severe pulmonary insufficiency

No gender/age discrimination

Obsessional thoughts

No gender/age discrimination

Spinal ataxia

No gender/age discrimination

Chronic psychosis

No gender/age discrimination

Sleep apnoea syndrome

No gender/age discrimination

Respiratory depression

No gender/age discrimination

Myasthenia gravis

No gender/age discrimination