Therapeutic Indications

Amiloride is indicated for:

Hepatic cirrhosis with ascites

Irrespective of gender only Adults (18 - 65 years old)

In hepatic cirrhosis with ascites, amiloride hydrochloride usually provides adequate diuresis, with diminished potassium loss and less risk of metabolic alkalosis, when used alone. It may be used with more potent diuretics when a greater diuresis is required while maintaining a more balanced serum electrolyte pattern.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 5-10 mg daily

Congestive heart failure

Irrespective of gender only Adults (18 - 65 years old)

In congestive heart failure, amiloride hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 2.5-10.0 mg a day

Hypertension

Irrespective of gender only Adults (18 years old or older)

Although amiloride Hydrochloride may be used alone, its principal indication is as concurrent therapy with thiazides or more potent diuretics to conserve potassium during periods of vigorous diuresis and during long term maintenance therapy. In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 2.5-5.0 mg given once a day

Contraindications

Active ingredient Amiloride is contraindicated in the following cases:

Severe progressive renal disease

No gender/age discrimination

Administration of amiloride is contraindicated in severe progressive renal disease. Patients with increases in blood urea over 10mmol/l, serum creatinine over 130Āµmol/l, or with diabetes mellitus, should not receive amiloride hydrochloride without careful, frequent monitoring of serum electrolytes and blood urea levels. In renal impairment, use of a potassium conserving agent may result in rapid development of hyperkalaemia.

Hyperkalaemia (plasma potassium over 5.5mmol/l)

No gender/age discrimination

Administration of amiloride is contraindicated in hyperkalaemia.

Acute renal failure

No gender/age discrimination

Administration of amiloride is contraindicated in acute renal failure.

Pregnancy

No gender/age discrimination

Because clinical experience is limited, amiloride is not recommended for use during pregnancy. The routine use of diuretics in otherwise healthy pregnant women with or without mild oedema is not indicated because they may be associated with hypovolaemia, increased blood viscosity and decreased placental perfusion.

Foetal and neonatal jaundice, foetal bone marrow depression and thrombocytopenia have also been described. The potential benefits of the drug must be weighed against the possible hazards to the foetus if it is administered to a woman of child bearing age.

Lithium

No gender/age discrimination

Lithium should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.

Diabetic nephropathy

No gender/age discrimination

Administration of amiloride is contraindicated in diabetic nephropathy.

Anuria

No gender/age discrimination

Administration of amiloride is contraindicated in anuria.

Addison's disease

No gender/age discrimination

Administration of amiloride is contraindicated in Addison’s disease.