Interactions

Active ingredient Ambroxol interacts in the following cases:

Impaired renal function, severe hepatic disease

Ambroxol must only be used with particular caution (i.e. at longer intervals or at a reduced dose) in impaired renal function or a severe hepatic disease. In severe renal insufficiency, an accumulation of the metabolites of ambroxol formed in the liver must be expected.

History of peptic ulcer disease

Since mucolytics may disrupt the gastric mucosal barrier ambroxol should be used with care in patients with a history of peptic ulcer disease.

Asthma, history of bronchospasm, severe respiratory failure, active tuberculosis

Ambroxol should be used with caution in asthmatic patients with a history of bronchospasm or severe respiratory failure or active tuberculosis.

Amoxycillin, cefuroxime, erythromycin

Following administration of ambroxol, the concentrations of antibiotics (amoxycillin, cefuroxime, erythromycin) in bronchopulmonary secretions and sputum are increased.

Pregnancy

There are no sufficient data for the use of ambroxol in pregnant women. This particularly concerns the period up to the 28th week of pregnancy. Ambroxol has shown no teratogenic effects in animal-experiment studies. Ambroxol should only be used in pregnancy after careful benefit/risk evaluation, particularly during the first trimester.

Nursing Mothers

Ambroxol crosses into the breast milk in animals. As there is no adequate experience in humans to date, ambroxol should only be used in lactation after careful benefit/risk assessment.

Carcinogenesis, Mutagenesis and Fertility

Fertility

There are no sufficient data about the influence of ambroxol on fertility in humans. In animalexperiment studies, ambroxol showed no influence on fertility.

Effects on Ability to Drive and Use Machines

There is no evidence for an effect on the ability to drive and use machines. Studies on the effects on the ability to drive and use machines have not been performed.