Adenine Deoxy Nucleoside

Adenosine Adenyldeoxyriboside Deoxyadenosine Desoxyadenosine Adenine Deoxyribonucleoside Adenine Deoxyribose Adenine Nucleoside Adenine Riboside

Interactions

Active ingredient Adenine Deoxy Nucleoside interacts in the following cases:

Severe heart failure

Adenosine should be used with caution in patients with severe heart failure that could be transiently aggravated during infusion.

Pericarditis or pericardial effusion

Because it has the potential to cause significant hypotension, adenosine should be used with caution in patients with pericarditis or pericardial effusion.

First degree A-V block, bundle branch block

Adenosine should be used with caution in patients with recent myocardial infarction, severe heart failure, or in patients with minor conduction defects (first degree A-V block, bundle branch block) that could be transiently aggravated during infusion.

Atrial fibrillation or flutter

Adenosine should be used with caution in patients with atrial fibrillation or flutter and especially in those with an accessory by-pass tract since particularly the latter may develop increased conduction down the anomalous pathway.

Breast-feeding

It is unknown whether adenosine metabolites are excreted in human milk. Adenosine should not be used during breast-feeding.

Pregnancy

There are no or limited amount of data from the use of adenosine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity. Adenosine is not recommended during pregnancy unless the physician considers the benefits to outweigh the potential risks.

Xanthines

Aminophylline, theophylline and other xanthines are competitive adenosine antagonists and should be avoided for 24 hours prior to use of adenosine. Food and drinks containing xanthines (tea, coffee, chocolate and cola) should be avoided for at least 12 hours prior to use of adenosine. 2

Uncorrected hypovolemia

Because it has the potential to cause significant hypotension, adenosine should be used with caution in patients with uncorrected hypovolemia.

Recent heart transplantation

In patients with recent heart transplantation (less than 1 year) an increased sensitivity of the heart to adenosine has been observed.

Left main coronary stenosis

Because it has the potential to cause significant hypotension, adenosine should be used with caution in patients with left main coronary stenosis.

Recent myocardial infarction

Adenosine should be used with caution in patients with recent myocardial infarction that could be transiently aggravated during infusion.

Left to right shunt

Because it has the potential to cause significant hypotension, adenosine should be used with caution in patients with left main coronary stenosis, uncorrected hypovolemia, stenotic valvular heart disease, left to right shunt.

Stenotic valvular heart disease

Because it has the potential to cause significant hypotension, adenosine should be used with caution in patients with stenotic valvular heart disease.

Autonomic dysfunction or stenotic carotid artery disease with cerebrovascular insufficiency

Because it has the potential to cause significant hypotension, adenosine should be used with caution in patients with autonomic dysfunction or stenotic carotid artery disease with cerebrovascular insufficiency.

History of convulsions/seizures

Adenosine may trigger convulsions in patients who are susceptible to convulsions. In patients with history of convulsions/seizures, the administration of adenosine should be carefully monitored.

Pregnancy

There are no or limited amount of data from the use of adenosine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity. Adenosine is not recommended during pregnancy unless the physician considers the benefits to outweigh the potential risks.

Nursing Mothers

It is unknown whether adenosine metabolites are excreted in human milk.

Adenosine should not be used during breast-feeding.