Therapeutic Indications

Acetazolamide is indicated for:

Prophylaxis of mounting to high altitude

Irrespective of gender only Adults (18 - 65 years old)

Acetazolamide is suitable for altitude sickness prevention and treatment. Acetazolamide is the superior drug for acute mountain sickness prevention due to its proven efficacy over the years in a large number of trials with an acceptable side-effect profile.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 250mg before climbing a mountain

Secondary or acute narrow angle glaucoma

Irrespective of gender only Adults (18 years old or older)

Acetazolamide is an enzyme inhibitor which acts specifically on carbonic anhydrase. Acetazolamide is useful in glaucoma (chronic simple (open angle) glaucoma, secondary glaucoma and perioperatively in acute angle closure glaucoma where delay of surgery is desired in order to lower intraocular pressure) because it acts on inflow, decreasing the amount of aqueous secretion.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 250mg/4h or 12 hours

Treatment 2: Oral - 500 mg once and then 125-500 mg/4h

Treatment 3: Intravenous - 250-1000mg per 24 hours

Chronic simple glaucoma (open angle)

Irrespective of gender only Adults (18 years old or older)

Acetazolamide is an enzyme inhibitor which acts specifically on carbonic anhydrase. It is indicated in the treatment of glaucoma. Acetazolamide is useful in glaucoma (chronic simple (open angle) glaucoma, secondary glaucoma and perioperatively in acute angle closure glaucoma where delay of surgery is desired in order to lower intraocular pressure) because it acts on inflow, decreasing the amount of aqueous secretion.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 250-1000mg per 24 hours

Epilepsy

Irrespective of gender only Adults (18 years old or older)

Acetazolamide is indicated for the treatment of epilepsy.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 250-1000 mĪ³ in 4 divided doses daily

Treatment 2: Oral - 8-30mg/kg/24h in divided doses

Treatment 3: Intravenous - 8-30 mg/kg in 2 divided doses daily

Congestive heart failure oedema, drug induced oedema

Irrespective of gender only Adults (18 years old or older)

Acetazolamide is indicated in the treatment of congestive heart failure, drug-induced oedema.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral - 250-375mg once daily in the morning

Epilepsy

Irrespective of gender only Minors (0 - 18 years old)

Acetazolamide is indicated for the treatment of epilepsy.

For this indication, the medical literature mentions below treatments (click for details):

Treatment 1: Oral

Treatment 2: Intravenous

Contraindications

Active ingredient Acetazolamide is contraindicated in the following cases:

Marked renal impairment

No gender/age discrimination

Acetazolamide is contra-indicated in marked renal impairment.

Marked liver dysfunction

No gender/age discrimination

Acetazolamide is contraindicated in marked liver dysfunction.

Suprarenal gland failure

No gender/age discrimination

Acetazolamide is contra-indicated in suprarenal gland failure.

Depressed levels of sodium

No gender/age discrimination

Acetazolamide is contraindicated in situations in which sodium blood levels are depressed.

Depressed levels of potassium

No gender/age discrimination

Acetazolamide is contraindicated in situations in which potassium blood levels are depressed.

Pregnancy

No gender/age discrimination

Acetazolamide has been reported to be teratogenic and embryotoxic in rats, mice, hamsters and rabbits at oral or parenteral doses in excess of ten times those recommended in human beings. Although there is no evidence of these effects in human beings, there are no adequate and well-controlled studies in pregnant women. Therefore, acetazolamide should not be used in pregnancy, especially during the first trimester.

Hyper-chloremic acidosis

No gender/age discrimination

Acetazolamide is contraindicated in hyper-chloremic acidosis.