Anatomical Therapeutic Chemical Classification System
Chloroquine binds to and alters the properties of DNA. Chloroquine also binds to ferriprotoporphyrin IX and this leads to lysis of the plasmodial membrane. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite.
Hydroxychloroquine is a antimalarial agent with have several pharmacological actions which may be involved in their therapeutic effect in the treatment of rheumatic disease, but its role is not known.
Primaquine is an 8-aminoquinoline anti-protozoal agent. Primaquine is indicated for the radical cure (prevention of relapse) of Plasmodium vivax and Plasmodium ovale malaria.