ATC Group: L04AA26 Belimumab

Anatomical Therapeutic Chemical Classification System

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Belimumab

Hierarchical Position

Active Ingredients

Chemical substance
Description

Belimumab is a human IgG1╬╗ monoclonal antibody specific for soluble human B Lymphocyte Stimulator protein (BLyS, also referred to as BAFF and TNFSF13B). Belimumab blocks the binding of soluble BLyS, a B cell survival factor, to its receptors on B cells. Belimumab by binding BLyS inhibits the survival of B cells, including autoreactive B cells, and reduces the differentiation of B cells into immunoglobulin-producing plasma cells.