ATC Group: L02BB Anti-androgens

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Anti-androgens

Hierarchical Position

Contents

Code
Title
L02BB01
L02BB02
L02BB03
L02BB04
L02BB05

Active Ingredients

Chemical substance
Description

Apalutamide is an orally administered, selective Androgen Receptor (AR) inhibitor that binds directly to the ligand-binding domain of the AR. Apalutamide treatment decreases tumor cell proliferation and increases apoptosis leading to potent antitumor activity.

Bicalutamide is a non-steroidal antiandrogen, devoid of other endocrine activity. It binds to androgen receptors without activating gene expression, and thus inhibits the androgen stimulus. Regression of prostatic tumours results from this inhibition.