ATC Group: B01AD11 Tenecteplase

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Tenecteplase

Hierarchical Position

Level
Code
Title
4
B01AD
5
B01AD11
Tenecteplase

Active Ingredients

Chemical substance
Description

Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.