ATC Group: A10BG Thiazolidinediones

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Thiazolidinediones

Hierarchical Position

Contents

Code
Title
A10BG01
A10BG02
A10BG03

Active Ingredients

Chemical substance
Description

Pioglitazone effects may be mediated by a reduction of insulin resistance. Pioglitazone appears to act via activation of specific nuclear receptors (peroxisome proliferator activated receptor gamma) leading to increased insulin sensitivity of liver, fat and skeletal muscle cells in animals. Treatment with pioglitazone has been shown to reduce hepatic glucose output and to increase peripheral glucose disposal in the case of insulin resistance.

Rosiglitazone is a selective agonist at the PPARĪ³ (peroxisomal proliferator activated receptor gamma) nuclear receptor and is a member of the thiazolidinedione class of anti-diabetic agents. It reduces glycaemia by reducing insulin resistance at adipose tissue, skeletal muscle and liver.