ATC Group: A04AD Other antiemetics

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Other antiemetics

Hierarchical Position

Contents

Code
Title
A04AD01
A04AD02
A04AD04
A04AD05
A04AD10
A04AD11
A04AD12
A04AD14

Active Ingredients

Chemical substance
Description

Aprepitant is a selective high-affinity antagonist at human substance P neurokinin 1 (NK1) receptors.

Dimenhydrinate is a theoclate salt of the ethanolamine derivative diphenhydramine. It exhibits reversible competitive antagonism with histamine for the capture of H1 receptors. It has anticholinergic (antimuscarinic) properties that explain the anti-emetic action of the drug in cases of labyrinthial irritation (nausea, vertigo), and the central suppression it causes.

Fosaprepitant is the prodrug of aprepitant and when administered intravenously is converted rapidly to aprepitant. The contribution of fosaprepitant to the overall antiemetic effect has not fully been characterised, but a transient contribution during the initial phase cannot be ruled out.

Rolapitant is a selective antagonist of human substance P/neurokinin 1 (NK1) receptors.