ATC Group: A04AA Serotonin (5HT3) antagonists

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Serotonin (5HT3) antagonists

Hierarchical Position

Level
Code
Title
4
A04AA
Serotonin (5HT3) antagonists

Contents

Code
Title
A04AA01
A04AA02
A04AA03
A04AA04
A04AA05

Active Ingredients

Chemical substance
Description

Granisetron is a potent anti-emetic and highly selective antagonist of 5-hydroxytryptamine (5HT3 receptors). Pharmacological studies have demonstrated that granisetron is effective against nausea and vomiting as a result of cytostatic therapy.

Netupitant is a selective antagonist of human substance P/neurokinin 1 (NK1) receptors. Delayed emesis has been associated with the activation of tachykinin family neurokinin 1 (NK1) receptors (broadly distributed in the central and peripheral nervous systems) by substance P. As shown in in vitro and in vivo studies, netupitant inhibits substance P mediated responses.

Ondansetron is a potent, highly selective 5HT3 receptor-antagonist. Its precise mode of action in the control of nausea and vomiting is not known.

Palonosetron is a selective high-affinity receptor antagonist of the 5HT3 receptor.

Tropisetron is a highly potent and selective competitive antagonist of the 5-HT3 receptor. Tropisetron selectively blocks the excitation of the presynaptic 5-HT3 receptors of the peripheral neurons in this reflex, and may exert additional direct actions within the CNS on 5-HT3 receptors mediating the actions of vagal input to the area postrema.